Pharmacological properties Pharmacodynamics immunostimulatory drug with antiviral action. Is a proviron for sale containing inosine and VD-dimethylamino-2-propanol in a molar ratio of 1: 3. The effectiveness of the proviron for sale is determined by the presence of inosine, the second component increases its availability to lymphocytes. Groprinosin stimulates biochemical processes in macrophages, enhances the production of interleukin enhances the synthesis of antibodies, enhances proliferation of T lymphocytes, T helper, natural killer cells. It stimulates the chemotactic and phagocytic activity of monocytes, macrophages and polymorphonuclear cells. Groprinosin inhibits replication of viral DNA and RNA by ribosome binding cells and changes its stereochemical structure. The drug is well tolerated, because It has low toxicity. It can be given to patients in the elderly suffering from angina or chronic heart failure. With timely application of the drug reduced the incidence of viral infections, reduces the duration and severity of the disease. Use of the drug is indicated in patients with poor immune, protected.When assigning Groprinosina as a subsidiary drug for infectious lesions of the skin and mucous membranes, caused by the virus proviron for sale simplex more rapid healing of damaged surface than treatment in conventional manner. Less commonly, there are new vesicles, edema, erosion, and recurrence of the disease.Pharmacokinetics After oral administration, the drug is well absorbed from the digestive tract and exhibits good bioavailability. In the body quickly breaks down into metabolites and excreted through the kidneys. Inosine metabolization exposed on a cycle typical of purine nucleotides to form uric acid! which serum can sometimes increase. As a result, the formation of uric acid crystals in the urinary tract. Not detected drug accumulation in the body. Complete elimination of the drug and its metabolites are excreted occurs within 48 hours.
- Proviron for sale caused by viral infections in patients with normal and impaired immune systems / incl disease caused by the virus proviron for sale simplex (type Ki-Type II, genital proviron for sale and cold sores other localization);
- subacute sclerosing panencephalitis
- urolithiasis disease
- Children under 2 years
- During pregnancy and breastfeeding
Application of pregnancy and breastfeeding.
The drug should not be taken during pregnancy and lactation, t. To. The safety have not been established.
Dosing and Administration
The drug is administered orally at regular intervals (8 or 6 hours) 3-4 times a day. Tablets are taken after a meal with a small amount of water.
If the doctor does not prescribe otherwise, it usually takes:
- Adults: 6 to 8 tablets per day, divided into 3 – 4 reception;
- Children from 2 to 12 years: 50 mg / kg of body weight per day, divided into 3 – 4 reception;
Equally, in both adults and children, in serious infectious diseases dose may be increased individually under medical supervision to 100 mg / kg of body weight per day, divided in 4 – 6 steps. The drug is usually applied for 5 days, and sometimes longer, depending on the disease. After an 8-day break, and treatment can be repeated.
In the initial period of treatment may reduce appetite, nausea, vomiting, diarrhea; a slight increase in the concentration of uric acid in the blood and urine; allergic reactions.
Interactions with other medications
The effectiveness of reducing immunosuppressants.
The drug should not be used with hyperuricemia (increased concentration of uric acid in the blood) due to the possibility of increasing the level of uric acid in the serum and urine. If, proviron for sale in spite of everything, the drug will be applied, it is necessary to regularly analyze the level of uric acid in the body. Patients with significantly elevated levels of uric acid can simultaneously receive drugs that lower its level. Patients with acute liver failure the dose should be reduced, as drug metabolization process occurs in the liver. In elderly patients there is no need to change the dose.
Effects on ability to drive vehicles and servicing mechanical equipment.
For patients receiving Groprinosin, there are no special contraindications to vehicles driving facilities and services moving mechanisms.
The release form
: 10 tablets in a blister made of PVC film and aluminum foil.
In 2 or 5 blisters with instruction on use in carton box.
Do not use in patients with expiration date.
Store in a dry dark place at room temperature not exceeding 25 ° C
. Keep out of the reach of children!