Proviron buy phosphate is inactive in vitro, but after application to the skin rapidly hydrolyzed phosphatases in the ducts of the sebaceous glands to form proviron buy having antibacterial activity. It shows the sensitivity of all tested strains , which explains the efficacy in treating acne vulgaris. After application to the skin of proviron buy free fatty acids on the skin surface is reduced from about 14% to 2% .
After external application of 1% proviron buy phosphate gel in serum and urine are determined by very low concentrations of proviron buy.
Shown comedones proviron buy activity in patients with acne vulgaris. The average concentration of the antibiotic in the content comedo after application of proviron buy solution in isopropyl alcohol and water (10 mg / ml) for 4 weeks averaged 597 .mu.g / g comedo content (0-1490 .mu.g / g).
Hypersensitivity to lincomycin or klindamitsiiu history.
age 12 years (Safety and efficacy data are not available).
USE IN PREGNANCY OR LACTATION
In animal studies, when administered at doses of proviron buy 100-600 mg / kg / day subcutaneously or into fertility impairment, and no teratogenic effects were found. Adequate controlled studies in pregnant women have been conducted. Since the results from animal studies can not always be extrapolated to man, the drug should be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
It is not known whether proviron buy in breast milk after topical application stands out.
proviron buy is found in breast milk after oral or parenteral administration, therefore, caution should be exercised when administering the drug during breastfeeding.
DOSAGE AND ADMINISTRATION
Topical. A thin layer of gel is applied to the affected area clean, dry skin 2 times per day. Course of treatment: to obtain satisfactory results, treatment should be continued for 6-8 weeks and can be extended to 6 months if necessary.
The most frequently – dryness of the skin.
Less common: abdominal pain, skin irritation, gastrointestinal disorders (diarrhea, nausea, vomiting), contact dermatitis, burning sensation in the eyes, folliculitis, caused by gram-negative flora, increased production of the sebaceous glands.
In extreme rare cases the development of colitis.
proviron buy phosphate local application can be absorbed in amounts that cause systemic effects.
INTERACTION WITH OTHER DRUGS
There is cross-resistance of microorganisms to proviron buy and lincomycin .
Antagonism was observed between proviron buy and erythromycin .
It was found that proviron buy violates neyromshechnuyu transmission and, therefore, may increase the effects of other muscle relaxants peripherally acting , so the drug should be used with caution in patients receiving preparations of this group.
Avoid getting the drug on the mucous membrane of the eyes and the mouth. After applying the gel to wash your hands thoroughly. Accidental contact with sensitive surfaces (eyes, skin abrasions, mucous membranes) should be given area, rinse with cool water.
The use of proviron buy (and other antibiotics), oral or parenteral, in some cases associated with the development of severe diarrhea and pseudomembranous colitis. When topical proviron buy cases of diarrhea and colitis are rare, however caution should be exercised, and in the development of severe or prolonged diarrhea, the drug should be discontinued and appropriate to carry out diagnostic and therapeutic measures, if necessary. In the case of severe diarrhea should decide whether colonoscopy.
Effects on ability to drive the vehicle and management mechanisms
There is no reason to believe that the use of Dalatsin drug can affect the ability to drive a car, and management mechanisms. metbol