Buy proviron online – alkylating antitumor agent acts on the chemical composition . The drug becomes active upon metabolism in the liver, releasing diazomethane. It is believed that there are three ways of action of buy proviron online: alkylation by carbonium ions, inhibition of purine bases and interaction with SH groups. The drug fazonespetsifichen.
The maximum plasma concentration is usually reached immediately after intravenous administration. Communication with the plasma proteins around 5%. It penetrates through the blood-brain barrier in small amounts. There is no evidence of its penetration into the placenta and breast milk.
Withdrawal of the drug from the body bi-phase with an initial half-life of about 20 minutes and the end – about 5 hours, these figures with abnormal liver or renal function is approximately 55 minutes and 7 hours, respectively. The drug undergoes hepatic microsomal Dimethylation fermenatami to form carbon dioxide, which is excreted in the exhaled air and aminoimidazolkarboksamida which is output in the urine. 40% of the drug is excreted by the kidneys in unchanged form mainly by glomerular filtration.
- soft tissue sarcoma (except Kaposi’s sarcoma)
There are reports on the efficacy of buy proviron online in combination with other cytostatic agents for the treatment of osteogenic sarcoma, uterine sarcoma, peritoneal and pleural mesothelioma, small cell lung cancer, thyroid cancer, carcinoid, pheochromocytoma, insulinoma, neuroblastoma and glioma.
- Hypersensitivity to buy proviron online or to any of the supporting components of the drug;
- a pronounced inhibition of bone marrow hematopoiesis;
- severe hepatic or renal failure;
- Pregnancy and lactation.
Precautions : When myelosuppression (including with concurrent radiation and chemotherapy), acute infectious diseases, viral (including chicken pox, herpes zoster), fungal or bacterial origin (risk of severe complications and generalization of the process) concomitant radiotherapy.
Dosing and Administration
The drug is administered only intravenously. The dosage and mode of administration selected individually.
Doses up to 200 mg / m² administered bolus slowly over 1-2 minutes. Higher doses should be administered in the form of an intravenous infusion over 15-30 minutes.
Usually used as monotherapy buy proviron online at a dose of 200-250 mg / m daily for 5 days; You can also instead of a 5-day course of the drug to enter the single dose of 850 mg / m². Repeated courses with an interval of 3 weeks.
When combined with other cytostatic buy proviron online is administered in a dose of 100-150 mg / m 4-5 consecutive days at intervals of four weeks or 375 mg / m² every 15 days.
Before administration the drug is diluted with water injection to achieve a concentration of 10 mg / ml. For a freshly prepared solution for infusion solution is diluted in 200-300 ml of 0.9% sodium chloride or 5% dextrose solution of sodium.
A solution of buy proviron online should be protected from light.
If abnormal liver function and / or renal impairment may require dose reduction.
Side effects are classified according to frequency: very often (≥1 / 10); commonly (≥1 / 100, <1/10); infrequently (≥1 / 1,000, ≤1 / 100); rare (≥1 / 10,000, ≤1 / 1,000 ); very rare (≤1 / 10,000). From the side of hematopoiesis: often – anemia, leukopenia, granulocytopenia, thrombocytopenia. Oppression myelopoiesis is dose-limiting side effect. Leykotsitopeniya usually observed on day 14, and thrombocytopenia – on day 18 after treatment and lasts an average of one week. Restoration of blood parameters occur in the 4th week. From the digestive system: often – nausea, vomiting, anorexia, stomatitis. Rarely – diarrhea, increased activity of “liver” enzymes. Very rarely – gepatonekroz due to occlusion of intrahepatic veins, possibly fatal (usually a syndrome observed during the second course of treatment). Some of its symptoms include fever, eosinophilia, abdominal pain, liver enlargement and shock, the severity of which increases rapidly for a few hours or days. From the urinary system: rarely – elevated levels of creatinine and urea in the urine. From the nervous system: rarely – headache, blurred vision, confusion, severe drowsiness, seizures, asthenic syndrome, paresthesia, hypoesthesia facial skin.reproductive system: often – amenorrhea, azoospermia. Allergic reactions: seldom – skin rash, redness of the skin, a feverish syndrome , anaphylactic reactions. skin and skin: rare – alopecia, hyperpigmentation and photosensitivity of the skin. Local reactions: rarely – pain at the injection site and along the vein; rarely – in contact with the drug under the skin – a sharp pain, necrosis of surrounding tissues. The other: seldom – flu-like symptoms, accession secondary infections, hepatic vein thrombosis, myalgia; long-term use increases the risk of tumor progression.
Symptoms: strengthening the suppression of bone marrow hematopoiesis and severity of dyspeptic disorders. Treatment: symptomatic, specific antidote is not known.
Interaction with other medicinal products and other forms of interaction
Drugs that induce microsomal liver enzymes (barbiturates, rifampicin, phenytoin), while the application may enhance the metabolism of buy proviron online.
The use of buy proviron online in combination with mercaptopurine, azathioprine and allopurinol increases the effects of
past and increases their toxicity.
buy proviron online can enhance the photosensitizing effect metoksipsoralena.
buy proviron online solution is chemically incompatible heparin, hydrocortisone, cysteine and sodium bicarbonate.
Compatible with other antitumor agents (bleomycin, cisplatin, 5-fluorouracil, vincristine, and others.) and prednisone.
buy proviron online should be used under the supervision of a physician who has experience with anticancer drugs.
During and after the treatment is necessary to monitor patterns of peripheral blood, kidney function, liver function and its size.
In the event of violations of the liver or kidneys, symptoms of hypersensitivity to the drug or thrombosis of the hepatic veins buy proviron online treatment should be stopped immediately.
When the first signs of extravasation buy proviron online (burning or pain at the injection site) administration should be discontinued immediately. The rest of the dose should be introduced into another vein.
During treatment and for 6 months after it should use reliable methods of contraception.
During therapy buy proviron online can not be vaccinated with vaccines containing live pathogens.
In the event of such adverse reactions of the nervous system as confusion, headache, drowsiness, convulsions, should refrain from driving and other activities requiring full attention.
Lyophilizate for preparation of solution for intravenous administration of 100 mg or 200 mg of dark glass bottles, sealed with chlorobutyl stopper and run-aluminum cap with a polypropylene cover type “flip-off white (100 mg) and green (200 mg) in color. At 1 and 10 bottles with instructions for use in a carton box. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk